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One is whether the trial truly brings something new

Am J Psychiatry 154:4268 Guaraldi GP, Fava M, Mazzi F, la Greca P (1993) An open trial of methyltetrahydrofolate in elderly depressed patients

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Thus, such a particular background strongly opposes the particular isoprenaline damaging effect, which seems to be NO system-related, as well [38]

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